Induction of differentiation in human promyelocytic leukemia HL-60 cell line by niacin-related compounds.

نویسندگان

  • Keiko Iwata
  • Shin Ogata
  • Katsuzumi Okumura
  • Hiroshi Taguchi
چکیده

Water-soluble vitamin, niacin, and its related compounds were examined for their differentiation-inducing activity in human promyelocytic leukemia cells (HL-60). Among the compounds, which inhibited cell proliferation measured by MTT assay, isonicotinic acid, nicotinamide N-oxide, and nicotinamide induced NBT reducing activity. HL-60 cells were differentiated into granulocyte-like cells by these compounds, judging from morphological changes and loss of nonspecific esterase activity. The differentiation-inducing activity of water-soluble vitamin and its related compounds suggest that these compounds may be applicable for medical use.

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عنوان ژورنال:
  • Bioscience, biotechnology, and biochemistry

دوره 67 5  شماره 

صفحات  -

تاریخ انتشار 2003